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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHRNA7
All Species:
33.64
Human Site:
T221
Identified Species:
67.27
UniProt:
P36544
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P36544
NP_000737.1
502
56449
T221
K
E
P
Y
P
D
V
T
F
T
V
T
M
R
R
Chimpanzee
Pan troglodytes
Q5IS52
529
59755
T256
A
E
I
Y
P
D
V
T
Y
A
F
I
I
R
R
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
T221
K
E
P
Y
P
D
V
T
F
T
V
T
M
R
R
Dog
Lupus familis
XP_545813
499
56257
T218
K
E
P
Y
P
D
V
T
F
T
V
T
I
R
R
Cat
Felis silvestris
Mouse
Mus musculus
P49582
502
56613
T221
K
E
P
Y
P
D
V
T
Y
T
V
T
M
R
R
Rat
Rattus norvegicus
Q05941
502
56484
T221
K
E
P
Y
P
D
V
T
Y
T
V
T
M
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517489
314
34257
V68
K
I
S
L
G
I
T
V
L
L
S
L
T
V
F
Chicken
Gallus gallus
P22770
502
56928
T221
K
E
P
Y
P
D
I
T
F
T
V
T
M
R
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957513
509
58038
T221
K
E
P
Y
P
D
V
T
F
T
V
V
M
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17644
576
65488
F252
A
E
P
Y
P
D
I
F
F
N
I
T
L
R
R
Honey Bee
Apis mellifera
NP_001073564
529
59946
T253
P
E
P
Y
V
D
V
T
F
T
I
Q
I
R
R
Nematode Worm
Caenorhab. elegans
P48180
498
57150
H220
P
E
P
Y
P
D
V
H
F
Y
L
H
M
R
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39.3
99
96.4
N.A.
93.4
93.4
N.A.
54.5
89.8
N.A.
75.2
N.A.
36.2
46.5
45.2
N.A.
Protein Similarity:
100
55.7
99.5
98
N.A.
97
97
N.A.
57.5
93.4
N.A.
85.8
N.A.
56
63.1
61.3
N.A.
P-Site Identity:
100
53.3
100
93.3
N.A.
93.3
93.3
N.A.
6.6
93.3
N.A.
93.3
N.A.
60
66.6
66.6
N.A.
P-Site Similarity:
100
66.6
100
100
N.A.
100
100
N.A.
6.6
100
N.A.
93.3
N.A.
80
80
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
92
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
92
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
67
0
9
0
0
0
9
% F
% Gly:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% H
% Ile:
0
9
9
0
0
9
17
0
0
0
17
9
25
0
0
% I
% Lys:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
9
0
0
0
0
9
9
9
9
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
59
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
17
0
84
0
84
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
92
92
% R
% Ser:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
9
75
0
67
0
59
9
0
0
% T
% Val:
0
0
0
0
9
0
75
9
0
0
59
9
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
92
0
0
0
0
25
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _